Clock control and efficiency are vital

Season storylines

Both teams enter the season opener dealing with recent injury history, though both squads are looking for fresh starts with new offensive coaching additions.

Defense analysis

The Chargers have maintained a top-tier defensive unit for consecutive seasons despite injuries and personnel questions, while the Cardinals continue seeking production from high-draft-capital prospects.

Victory keys

Success in the opener depends on controlling the clock through a strong running game and executing efficiently on first downs to avoid negative plays.